Table 1 Cohort demographics.

From: Analysis of rare Parkinson’s disease variants in millions of people

 

23andMe

AMP-PD

UKB

Total

Cases, n

25,034

1451

1105 (+6701 proxies)a

27,590 (+6701 proxies)

Age, mean ± SD

72.3 (±10.9)b

61.3 (±10.2)c

59.1 (±7.1)d

 

Male %

59.9

63.7

45.6

 

Controls

3,065,473

2,556

38,051

3,106,080

Age, mean ± SD

50.1 (±17.5)

70.7 (±13.2)c

64.1 (±2.8)d

 

Male %

43.5

49.8

48.6

 

Nominated variants

692

301

644

 

Type of data

Imputed genotype data

Whole genome sequencing

Whole exome sequencing

 
  1. UKB UK Biobank, AMP-PD Accelerating Medicines Partnership Parkinson’s disease
  2. aProxies in UK Biobank data include: 6033 parents and 668 siblings.
  3. bCurrent age at time of analysis.
  4. cAge at analysis for AMP-PD.
  5. dAge at recruitment for UK Biobank data.
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