Table 2 Robust Mendelian randomization analysis of association between ganglion cell inner plexiform layer thickness and Parkinson’s disease.
RAPS | MR-Egger | WME | Weighted MBE | |||||
|---|---|---|---|---|---|---|---|---|
Outcome | Beta or OR (95%CI) | P | Beta or OR (95%CI) | P | Beta or OR (95%CI) | P | Beta or OR (95%CI) | P |
Risk | 1.006 (0.982,1.029) | 0.641 | 1.029 (0.925,1.144) | 0.606 | 1.014 (0.980,1.049) | 0.436 | 1.016 (0.973,1.061) | 0.482 |
Constipation | 0.900 (0.771,1.051) | 0.184 | 1.026 (0.727,1.446) | 0.889 | 0.947 (0.773,1.159) | 0.595 | 0.964 (0.742,1.253) | 0.790 |
Daytime sleepiness | 0.960 (0.823,1.120) | 0.605 | 1.067 (0.754,1.510) | 0.722 | 0.930 (0.751,1.150) | 0.502 | 0.893 (0.653,1.220) | 0.493 |
Dementia | 1.076 (0.924,1.253) | 0.348 | 0.991 (0.700,1.402) | 0.960 | 1.061 (0.879,1.280) | 0.537 | 1.039 (0.817,1.322) | 0.759 |
Depression | 1.104 (0.933,1.305) | 0.249 | 1.185 (0.811,1.730) | 0.403 | 1.059 (0.870,1.289) | 0.569 | 1.056 (0.814,1.372) | 0.689 |
Dyskinesias | 1.089 (0.901,1.318) | 0.377 | 1.059 (0.691,1.623) | 0.800 | 0.988 (0.767,1.273) | 0.929 | 0.946 (0.635,1.410) | 0.794 |
HY3 | 1.059 (0.848,1.322) | 0.613 | 1.056 (0.635,1.757) | 0.838 | 1.120 (0.838,1.497) | 0.445 | 1.138 (0.703,1.843) | 0.611 |
Hyposmia | 1.017 (0.881,1.174) | 0.816 | 1.075 (0.774,1.493) | 0.676 | 0.997 (0.825,1.204) | 0.971 | 0.981 (0.745,1.292) | 0.894 |
Insomnia | 1.090 (0.963,1.234) | 0.172 | 1.218 (1.027,1.445) | 0.047 | 1.123 (0.959,1.315) | 0.148 | 1.126 (0.910,1.393) | 0.299 |
Motor fluctuation | 0.982 (0.834,1.158) | 0.832 | 1.244 (0.878,1.763) | 0.266 | 0.962 (0.782,1.183) | 0.713 | 0.936 (0.712,1.229) | 0.648 |
RBD | 1.199 (0.972,1.479) | 0.091 | 1.461 (0.893,2.391) | 0.166 | 1.328 (1.019,1.730) | 0.036 | 1.354 (0.935,1.960) | 0.140 |
AAO | −0.054 (−0.210,0.103) | 0.503 | −0.144 (−0.514,0.226) | 0.455 | −0.037 (−0.241,0.167) | 0.722 | −0.006 (−0.276,0.264) | 0.968 |
UPDRS total | 0.012 (−0.032,0.057) | 0.592 | −0.003 (−0.091,0.085) | 0.951 | 0.038 (−0.021,0.097) | 0.203 | 0.038 (−0.047,0.123) | 0.397 |
UPDRS1 | −0.011 (−0.064,0.041) | 0.676 | 0.000 (−0.117,0.117) | 0.999 | 0.001 (−0.065,0.067) | 0.967 | 0.002 (−0.075,0.079) | 0.963 |
UPDRS2 | −0.023 (−0.076,0.031) | 0.409 | 0.052 (−0.067,0.171) | 0.415 | −0.031 (−0.100,0.039) | 0.391 | −0.040 (−0.135,0.054) | 0.427 |
UPDRS3 | −0.022 (−0.068,0.024) | 0.347 | −0.068 (−0.170,0.035) | 0.230 | −0.015 (−0.076,0.045) | 0.616 | −0.011 (−0.096,0.073) | 0.800 |
UPDRS4 | −0.004 (−0.053,0.045) | 0.865 | 0.025 (−0.037,0.087) | 0.454 | 0.014 (−0.047,0.075) | 0.654 | 0.019 (−0.047,0.084) | 0.587 |
MMSE | 0.009 (−0.082,0.101) | 0.839 | −0.019 (−0.185,0.147) | 0.829 | 0.029 (−0.092,0.150) | 0.641 | 0.042 (−0.097,0.182) | 0.567 |
MoCA | −0.067 (−0.306,0.172) | 0.581 | 0.060 (−0.452,0.572) | 0.827 | −0.209 (−0.509,0.092) | 0.173 | −0.242 (−0.689,0.205) | 0.325 |
SEADL | −0.160 (−0.578,0.258) | 0.453 | 0.028 (−0.728,0.783) | 0.944 | 0.133 (−0.394,0.660) | 0.622 | 0.151 (−0.551,0.854) | 0.680 |
