Fig. 8: Representative confocal images depicting the maturation of Lewy body pathology (N-terminus α-Syn; 849102) in the human brain with PD. | npj Parkinson's Disease

Fig. 8: Representative confocal images depicting the maturation of Lewy body pathology (N-terminus α-Syn; 849102) in the human brain with PD.

From: Aggregate-prone brain regions in Parkinson’s disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility

Fig. 8

a, b Granular and punctate α-Syn aggregates begin to accumulate in the neuronal cytoplasm but do not yet exhibit a structured morphology. c Irregularly shaped aggregates begin to condense and expand within the cytoplasm. d, e Aggregates continue to expand within the confines of the intracellular space and gradually become more structurally well-defined and uniformly labelled. f Classical Lewy body morphology becomes structurally well-defined, characterised by a peripherally condensed halo. g, h Aggregates eventually outgrow the confines of the intracellular space and rupture the cellular membrane, allowing growth to continue within the extracellular space. i Distinct Lewy bodies can interact with one another and (j, k) merge to form compound extracellular aggregate structures. Asterisks define the distance measured in each image. Scale bar, 10 μm.

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