Table 1 Participants’ characteristics.
From: Proxy-analysis of the genetics of cognitive decline in Parkinson’s disease through polygenic scores
Characteristic | DIGPD | Iceberg | PPMI | PDBP | SURE-PD3 | LCC | p-value |
|---|---|---|---|---|---|---|---|
Number of participants | 387 | 144 | 465 | 784 | 246 | 63 | |
Age at baseline (in years) | 62.37 ± 9.63 | 62.94 ± 9.22 | 61.77 ± 9.71 | 64.49 ± 9.01 | 62.71 ± 9.50 | 68.03 ± 9.74 | 1.11e–08 |
Sex (F/M) | 156/231 (40%) | 52/92 (36%) | 165/300 (35%) | 283/501 (36%) | 119/127 (48%) | 22/41 (35%) | 4.39e–15 |
Length of follow-up (in years) | 5.13 ± 1.91 | 3.73 ± 1.36 | 5.23 ± 2.85 | 1.39 ± 1.60 | 2.04 ± 0.68 | 2.22 ± 1.92 | 6.97e–230 |
Interval between visits (in years) | 1.09 ± 0.32 | 1.11 ± 0.27 | 1.06 ± 0.28 | 1.05 ± 0.24 | 0.79 ± 0.26 | 1.47 ± 0.70 | 8.28e–152 |
Baseline cognitive score | MMSE: 28.18 ± 1.90 | MoCA: 27.53 ± 1.98 | MoCA: 27.12 ± 2.32 | MoCA: 25.37 ± 3.51 | MoCA: 27.61 ± 1.88 | MoCA: 25.41 ± 4.42 | 3.65e–38 |
Baseline cognitive decline (yes/no) | 111/276 (29%) | 11/133 (8%) | 58/407 (12%) | 266/518 (34%) | 12/234 (5%) | 20/43 (32%) | 4.11e-–32 |
Lifetime cognitive decline (yes/no) | 241/146 (62%) | 35/109 (24%) | 189/276 (41%) | 350/434 (45%) | 28/218 (11%) | 30/33 (48%) | 1.90e-–37 |
rs7412–number of T alleles (0/1/2) | 337/49/1 | 126/18/0 | 392/68/5 | 673/106/5 | 221/23/2 | 51/12/0 | |
rs429358–number of C alleles (0/1/2) | 289/92/6 | 115/25/4 | 345/109/11 | 587/182/15 | 171/68/7 | 51/12/0 | |
Number of severe GBA mutations (0/1) | 387/0 | 144/0 | 464/1 | 781/3 | 245/1 | 63/0 | |
Number of mild GBA mutations (0/1/2) | 380/7/0 | 141/3/0 | 420/44/1 | 716/65/3 | 230/16/0 | 58/5/0 | |
Number of undetermined GBA mutations (0/1/2+) | 376/10/1 | 139/5/0 | 161/52/252 | 286/79/419 | 105/23/118 | 23/7/33 |
