Table 3 Interaction effects of PRS and nongenetic risk factors on AAO of PD.

1

Smoking

0.9681

0.2524

3.8350

0.0001

PRS

−0.7556

0.1671

−4.5210

<0.0001

Smoking × PRS

0.5348

0.2487

2.1500

0.0316*

2

Moderate or vigorous physical activate

1.3308

0.2953

4.5060

<0.0001

PRS

−0.0906

0.2373

−0.3820

0.7027

Moderate or vigorous physical activate × PRS

−0.5422

0.2897

−1.8710

0.0614

3

NSAID=s intake

0.6942

0.2687

2.5840

0.0098

PRS

−0.5125

0.1516

−3.3800

0.0007

NSAIDs intake × PRS

0.0045

0.2680

0.0170

0.9866

4

EDS

−2.4980

0.2542

−9.8260

<0.0001

PRS

−0.3187

0.1580

−2.0170

0.0438

EDS × PRS

−0.4719

0.2507

−1.8820

0.0599

5

Family history of PD

−1.7108

0.4356

−3.9280

<0.0001

PRS

−0.5699

0.1295

−4.4010

<0.0001

Family history of PD × PRS

0.8614

0.4439

1.9410

0.0524