Fig. 3: PPI networks seeded with PD-risk genes and associated GWAS SNPs identify traits that co-occur with PD. | npj Parkinson's Disease

Fig. 3: PPI networks seeded with PD-risk genes and associated GWAS SNPs identify traits that co-occur with PD.

From: Discovering genetic mechanisms underlying the co-occurrence of Parkinson’s disease and non-motor traits

Fig. 3

Traits-associated loci enriched within a PD-causal network and b PD-associated network. Traits identified at L0 of the PD-causal network are inferred to be comorbid traits of PD, whereas those identified at L0 of the PD-associated network are PD-associated traits. Regulatory loci associated with traits identified at L0-L3 of the PD-causal (blue dotted lines in a) and PD-associated (green dotted line in b) networks are modifiers of the PD-risk and PD-associated genes, respectively. Traits associated with both PD-causal and PD-associated networks are highlighted in yellow. c Target PD-risk genes of the regulatory loci associated with L0 traits within the PD-causal network and PD-associated network. Genes highlighted in bold font are PD-risk genes.

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