Fig. 6: Patient records confirm that diseases associated with the genes identified within the PD-causal network co-occur with PD. | npj Parkinson's Disease

Fig. 6: Patient records confirm that diseases associated with the genes identified within the PD-causal network co-occur with PD.

From: Discovering genetic mechanisms underlying the co-occurrence of Parkinson’s disease and non-motor traits

Fig. 6

a Mesh terms of diseases comorbid with PD in NZ. Odds ratios (OR) were calculated for the ICD10 codes for co-occurring conditions that overlapped gene-related medical conditions identified using DisGeNET data. Diseases with multiple ORs represent three-letter ICD10 categories or MeSH subheadings with more than one sub-category. For example, Melanoma (MeSH = D008545, ICD-10-AM = C43) has two sub-categories, C434 (Malignant melanoma of scalp and neck) and C433 (Malignant melanoma of other and unspecified parts of the face). Horizontal lines represent a 95% confidence interval. b PD-causal network genes are linked to both disease MeSH terms (orange) seen in NZ PD patients and GWAS traits (green) identified in our analysis (Fig. 3a).

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