Fig. 4: Preprocessing pipeline.

a Illustrates part one of the preprocessing with the computation of the DTI metrics and the registration to the T1-weighted (T1w) MRI subject space. b Depicts the registration of the subject’s T1-weighted MRI to the PD25 atlas; the transformation of the DTI metrics to the atlas space, and the computation of the affinely registered T1-weighted MRI and the log-Jacobian maps. c Showcases the use of the inverse Φy transformation to warp the atlas anatomical regions to the individual’s T1-weighted MRI space.