Table 1 Cohort demographics
From: Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level
Whole Cohort | GBA1/LRRK2 Negativeb | GBA1 Carriers | p | LRRK2 Carriers | p | |
|---|---|---|---|---|---|---|
N (%) | 1689 | 1483 | 159c | 44c | ||
Variant, n (%) | ||||||
GBA1 Risk | 94 (59) | |||||
GBA1 Mild | 42 (26) | |||||
GBA1 Severe | 23 (14) | |||||
LRRK2 G2019S | 41 (93)d | |||||
Sex, n (%)a | ||||||
Female | 608 (36) | 517 (35) | 67 (42) | 0.081 | 23 (51) | 0.048 |
Male | 1080 (64) | 965 (65) | 92 (58) | 21 (49) | ||
Ethnicity, n (%) | ||||||
Hispanic or Latino | 34 (2) | 31 (2) | 2 (1) | nt | 1 (2) | nt |
Not Hispanic or Latino | 1654 (98) | 1451 (98) | 157 (99) | 43 (98) | ||
Unknown or not reported | 1 (<1) | 1 (<1) | 0 (0) | 0 (0) | ||
Race, n (%) | ||||||
White | 1532 (91) | 1334 (90) | 155 (98) | nt | 40 (91) | nt |
Black or African American | 78 (5) | 76 (5) | 2 (1) | 0 (0) | ||
Am Indian/Alaska Native | 1 (<1) | 1 (<1) | 0 (0) | 0 (0) | ||
Asian | 56 (3) | 54 (4) | 0 (0) | 2 (4) | ||
More than one race | 9 (<1) | 6 (<1) | 2 (1) | 1 (2) | ||
Other | 5 (<1) | 4 (<1) | 0 (0) | 1 (2) | ||
Unknown or not reported | 8 (<1) | 8 (1) | 0 (0) | 0 (0) | ||
Age, mean (SD) | ||||||
At diagnosis | 62 (11) | 62 (11) | 61 (10) | 0.215 | 61 (11) | 0.347 |
At enrollment | 69 (9) | 69 (9) | 67 (9) | 0.049 | 70 (9) | 0.683 |
Clinical Presentation at Onset | ||||||
Tremor | 865 (51) | 764 (52) | 77 (49) | 0.482 | 22 (50) | 0.482 |
Gait Disorder | 191 (11) | 170 (11) | 18 (11) | 2 (5) | ||
Mixed | 120 (7) | 101 (7) | 16 (10) | 3 (7) | ||
Neither | 513 (31) | 448 (30) | 48 (30) | 17 (38) | ||
1st Degree Family History | ||||||
None | 1401 (83) | 1241 (84) | 128 (80) | 0.225 | 30 (68) | 0.002 |
PD | 155 (9) | 122 (8) | 20 (13) | 12 (27) | ||
Other NDD | 108 (6) | 99 (7) | 8 (5) | 1 (2) | ||
Both | 25 (2) | 21 (1) | 3 (2) | 1 (2) | ||
