Fig. 2: Parkin loss does not affect COX activity in the brain of mtDNA mutator mouse.
From: PARKIN is not required to sustain OXPHOS function in adult mammalian tissues
a Body weight measured in both female and male mice at 36 weeks of age. Data are represented as means ± s.e.m.; n ≥ 6 per group; ***p < 0.001, ns not significant. Representative images of COX enzyme activity in ventral midbrain section in 36-week-old mice measure using b, c. COX/SDH staining (Scale bars: 500 μm, 200 μm and 50 μm) and d–f NBTx histochemistry (Scale bars: 500 μm, 100 μm and 50 μm). Hippocampal brain sections of MILON mice (conditional Tfam KO in forebrain neurons, TfamloxP/loxP; +/CamKII-cre−) at 5 months of age were included as positive control. Different levels of COX deficiency from mild to severe marked as 1–3, respectively.
