Table 1 Baseline characteristics of participants stratified by incident PD
Baseline characteristics | Total | Non-PD | PD | P value* |
|---|---|---|---|---|
N | 109,790 | 109,146 | 644 | |
Age, mean(SD), years | 56.5 (8.10) | 56.5 (8.10) | 62.7 (5.57) | <0.001 |
Sex, N (%) | <0.001 | |||
Female | 59,073 (53.8) | 58,838 (53.9) | 235 (36.5) | |
Male | 50,717 (46.2) | 50,308 (46.1) | 409 (63.5) | |
Smoking status, N (%) | 0.156 | |||
Never | 59,704 (54.7) | 59,372 (54.7) | 332 (51.9) | |
Prior/current | 49,524 (45.3) | 49,216 (45.3) | 308 (48.1) | |
BMI, mean (SD) | 27.4 (4.77) | 27.4 (4.77) | 27.7 (4.50) | 0.182 |
Systolic blood pressure, mean(SD), mmHg | 137.7 (18.5) | 137.7 (18.5) | 141.2 (18.5) | <0.001 |
Currently on anti-hypertensive treatments, N (%) | 0.289 | |||
No | 99,368 (90.5) | 98,793 (90.5) | 575 (89.3) | |
Yes | 10,422 (9.49) | 10,353 (9.49) | 69 (10.7) | |
History of diabetes mellitus, N (%) | <0.001 | |||
No | 103,134 (93.9) | 102,574 (94.0) | 560 (87.0) | |
Yes | 6656 (6.06) | 6572 (6.02) | 84 (13.0) | |
History of hyperlipidemia, N (%) | 0.002 | |||
No | 58,947 (53.7) | 58,640 (53.7) | 307 (47.7) | |
Yes | 50,843 (46.3) | 50,506 (46.3) | 337 (52.3) | |
Prior stroke, N (%) | <0.001 | |||
No | 108,263 (98.6) | 107,643 (98.6) | 620 (96.3) | |
Yes | 1527 (1.39) | 1503 (1.38) | 24 (3.73) | |
Use of psychotropic medications, N (%) | 0.008 | |||
No | 100,974 (92.0) | 100,400 (92.0) | 574 (89.1) | |
Yes | 8816 (8.03) | 8746 (8.01) | 70 (10.9) | |
Presence of APOE allelic variant(s), N (%) | 0.004 | |||
No | 83,184 (75.8) | 82,727 (75.8) | 457 (71.0) | |
Yes | 26,606 (24.2) | 26,419 (24.2) | 187 (29.0) | |
Presence of GBA allelic variant(s), N(%) | <0.001 | |||
No | 104,519 (95.2) | 103,930 (95.2) | 589 (91.5) | |
Yes | 5217 (4.80) | 5216 (4.78) | 55 (8.54) |
