Fig. 6: Diagnostic performance and correlation analysis.
From: Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
A Heatmap showing positive (yellow) and negative (blue) patients analyzed with TauK18 and TauK19 in ankle and cervical sites. B–H ROC curves analysis of TauK18 positivity/negativity in ankle (fuchsia), cervical (blue), and both sites (green). The referral line is reported in black. I The table provides the asymptotic significance, AUC with 95% CI, sensitivity, and specificity for each comparison. P-values < 0.05 were considered significant. J Box plot showing differences in age between subjects with seeding scores lower or higher than 0.5. Each dot represents a patient and bars the mean of the group. K Box plot showing differences in cervical TauK18 T50 between male and female subjects. Each dot represents a patient and bars the mean of the group. L Correlation between ankle TauK18 ThT fluorescence signal and H&Y in CBD (R = 0.865, P = 0.026, n = 6). The regression line is reported together with its 95% CI (dashed line).
