Table 1 Demographic and clinical characteristics of the three main groups of patients
From: Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Variable | HC (n = 14) | TAU (n = 24) | SYN (n = 20) | Overall P-Value | TAU vs HC | SYN vs HC | TAU vs SYN |
|---|---|---|---|---|---|---|---|
Age (y) | 59 ± 8 | 73 ± 8 | 66 ± 10 | 0.000 | 0.000 | 0.050 | 0.012 |
Sex (%M) | 50.0% | 62.5% | 65.0% | 0.661 | 0.339 | 0.301 | 0.558 |
Disease duration (y) | – | 4 ± 2 | 4 ± 3 | 0.614 | – | – | 0.614 |
Age of onset (y) | – | 69 ± 8 | 62 ± 10 | 0.015 | – | – | 0.015 |
H&Y | – | 3.0 [2.0–4.0] | 2.3 [1.0–3.0] | 0.118 | – | – | 0.118 |
UPDRS-I | – | 8.0 [6.0–9.0] | 7.0 [3.0–11.5] | 0.702 | – | – | 0.710 |
UPDRS-II | – | 10.0 [3.0–26.0] | 7.0 [3.0–13.5] | 0.408 | – | – | 0.418 |
UPDRS-III | – | 33.0 [21.0–51.0] | 17.5 [10.0–27.5] | 0.008 | – | – | 0.008 |
UPDRS-TOT | – | 42.0 [25.0–61.0] | 33.0 [17.5–50.0] | 0.294 | – | – | 0.318 |
COMPASS-31_OH | – | 0.0 [0.0–0.0] | 6.0 [0.0–16.0] | 0.049 | – | – | 0.099 |
COMPASS-31_VM | – | 0.0 [0.0–0.0] | 0.0 [0.0–0.0] | 0.970 | – | – | 1.000 |
COMPASS-31_SM | – | 4.0 [0.0–6.3] | 3.2 [0.0–6.3] | 0.964 | – | – | 0.965 |
COMPASS-31_GI | – | 1.5 [0.0–4.0] | 4.9 [0.2–6.9] | 0.032 | – | – | 0.035 |
COMPASS-31_BL | – | 2.0 [0.0–3.0] | 0.0 [0.0–1.1] | 0.128 | – | – | 0.149 |
COMPASS-31_PM | – | 0.0 [0.0–2.0] | 0.0 [0.0–2.0] | 0.911 | – | – | 0.919 |
COMPASS-31_TOT | – | 10.5 [4.7–18.8] | 18.5 [6.3–30.6] | 0.148 | – | – | 0.149 |
BDI-II | – | 7.0 [5.0–15.0] | 8.0 [4.0–14.0] | 0.554 | – | – | 0.562 |
MMSE | – | 26.5 [22.8–27.8] | 29.0 [29.0–30.0] | 0.003 | – | – | 0.002 |
MoCA | – | 21.0 [17.3–22.8] | 27.0 [25.0–28.0] | 0.005 | – | – | 0.004 |
FAB | – | 12.0 [8.0–14.5] | – | – | – | – | – |
Smell test | – | 9.0 [8.3–10.8] | 6.0 [4.0–10.0] | 0.092 | – | – | 0.095 |
RBDSQ | – | 0.0 [0.0–2.0] | 2.5 [1.0–5.0] | 0.012 | – | – | 0.012 |
LEDD | – | 400.0 [0.0–600.0] | 288.0 [0.0–625.0] | 0.945 | – | – | 1.957 |
