Table 2 Demographic and clinical characteristics of subgroups of patients based on the clinical diagnosis
From: Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Variable | HC (n = 14) | PSP (n = 18) | CBD (n = 6) | PD (n = 14) | MSA (n = 6) | Overall P-value | PSP vs HC | CBD vs HC | PD vs HC | MSA vs HC | PSP vs CBD | PSP vs PD | PSP vs MSA | CBD vs PD | CBD vs MSA | PD vs MSA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | 59 ± 8 | 72 ± 7 | 74 ± 10 | 66 ± 10 | 64 ± 8 | 0.001 | 0.000 | 0.020 | 0.044 | 0.312 | 0.454 | 0.077 | 0.040 | 0.109 | 0.132 | 0.718 |
Sex (%M) | 50.0% | 66.7% | 50.0% | 71.4% | 50.0% | 0.702 | 0.278 | 0.685 | 0.220 | 0.686 | 0.397 | 0.541 | 0.397 | 0.336 | 0.716 | 0.397 |
Disease duration | – | 4 ± 2 | 3 ± 1 | 4 ± 4 | 4 ± 3 | 0.778 | – | – | – | – | 1.000 | 0.408 | 0.759 | 0.579 | 0.699 | 0.639 |
Age of onset | – | 69 ± 7 | 70 ± 11 | 63 ± 10 | 60 ± 8 | 0.095 | – | – | – | – | 0.431 | 0.133 | 0.036 | 0.087 | 0.065 | 0.467 |
H&Y | – | 3.0 [3.0–4.0] | 2.0 [1.8–3.3] | 2.0 [1.0–3.0] | 2.8 [1.9–5.0] | 0.043 | – | – | – | – | 0.062 | 0.021 | 0.658 | 0.718 | 0.394 | 0.207 |
UPDRS-I | – | 8.0 [6.0–9.0] | – | 5.0 [2.5–10.5] | 10.5 [7.0–16.2] | 0.252 | – | – | – | – | – | 0.351 | 0.315 | – | – | 0.163 |
UPDRS-II | – | 10.0 [3.0–26.0] | – | 6.0 [3.0–11.0] | 10.5 [3.3–14.8] | 0.573 | – | – | – | – | – | 0.351 | 1.000 | – | – | 0.549 |
UPDRS-III | – | 40.0 [21.0–51.5] | 27.0 [15.3–41.5] | 18.0 [7.0–23.5] | 17.0 [12.5–48.5] | 0.059 | – | – | – | – | 0.280 | 0.003 | 0.227 | 0.179 | 1.000 | 0.443 |
UPDRS-TOT | – | 42.0 [25.0–61.0] | – | 28.0 [14.5–50.0] | 40.5 [24.0–70.5] | 0.391 | – | – | – | – | – | 0.241 | 1.000 | – | – | 0.412 |
COMPASS-31_OH | – | 0.0 [0.0–0.0] | 0.0 [0.0–24.0] | 6.0 [0.0–17.0] | 6.0 [0.0–19.0] | 0.208 | – | – | – | – | 0.574 | 0.102 | 0.235 | 0.859 | 0.905 | 0.968 |
COMPASS-31_TOT | – | 11.0 [8.0–18.0] | 5.0 [1.0–24.0] | 15.4 [4.3–33.5] | 19.2 [8.9–29.5] | 0.482 | – | – | – | – | 0.738 | 0.331 | 0.235 | 0.432 | 0.381 | 0.659 |
BDI-II | – | 7.0 [5.0–15.0] | – | 5.0 [2.0–12.5] | 13.0 [7.5–14.5] | 0.234 | – | – | – | – | – | 0.250 | 0.438 | – | – | 0.156 |
MMSE | – | 26.5 [22.8–27.8] | – | 29.5 [28.8–30.0] | 29.0 [28.0–30.0] | 0.010 | – | – | – | – | – | 0.004 | 0.045 | – | – | 0.823 |
MoCA | – | 21.0 [17.3–22.8] | – | 27.0 [24.5–28.3] | 27.0 [24.5–27.5] | 0.018 | – | – | – | – | – | 0.008 | 0.030 | – | – | 0.823 |
FAB | – | 9.0 [6.0–12.5] | 14.5 [11.5–17.5] | – | – | 0.065 | – | – | – | – | 0.063 | – | – | – | – | – |
Smell test | – | 9.0 [8.3–10.8] | – | 5.5 [3.0–9.0] | 10.0 [6.0–11.5] | 0.045 | – | – | – | – | – | 0.020 | 0.833 | – | – | 0.107 |
RBDSQ | – | 1.0 [0.0–3.0] | 0.0 [0.0–0.0] | 3.0 [1.8–5.5] | 1.5 [0.0–5.3] | 0.019 | – | – | – | – | 0.081 | 0.032 | 0.609 | 0.008 | 0.114 | 0.353 |
LEDD | – | 425.0 [103.5–600.0] | 0.0 [0.0–350.0] | 288.0 [50.0–750.0] | 150.0 [0.0–537.5] | 0.225 | – | – | – | – | 0.109 | 0.846 | 0.178 | 0.117 | 0.537 | 0.416 |
