Table 3 Summary of VTA, SNc, and striatum unparcellated and parcellated subregion ANCOVAs in participants from local Western and PPMI data

From: Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease

 

Local Western

PPMI

Region

Main Effect of Group from ANCOVA (RBD vs ePD vs HC)

VTA, SNc

Bundle MD

Surface MD

Bundle FA

Surface FA

Bundle MD

Surface MD

Bundle FA

Surface FA

Unparcellated SNc

-

-

0.01

-

-

-

-

-

Limbic

-

-

-

-

-

-

-

-

Executive

-

-

0.01

0.004

-

-

-

-

Rostral Motor

-

-

<0.001

-

-

-

-

-

Caudal Motor

-

<0.001

<0.001

-

-

0.003

-

-

Striatum

Bundle MD

Surface MD

Bundle FA

Surface FA

Bundle MD

Surface MD

Bundle FA

Surface FA

Unparcellated

-

0.03

-

-

-

-

-

-

Limbic

-

-

-

-

-

-

-

-

Executive

-

<0.001

-

-

-

-

-

-

Rostral Motor

-

0.01

-

-

-

-

-

-

Caudal Motor

-

-

-

-

-

-

-

-

Parietal

-

<0.001

-

-

-

-

-

-

Occipital

-

<0.001

-

-

-

-

-

-

 

post-hoc comparisons (RBD vs HC)

VTA, SNc

Bundle MD

Surface MD

Bundle FA

Surface FA

Bundle MD

Surface MD

Bundle FA

Surface FA

Unparcellated SNc

-

-

0.03

-

-

-

-

-

Limbic

-

-

-

-

-

-

-

-

Executive

-

-

<0.001

<0.001

-

-

-

-

Rostral Motor

-

-

<0.001

-

-

-

-

-

Caudal Motor

-

<0.001

<0.001

-

-

0.002

-

-

Striatum

Bundle MD

Surface MD

Bundle FA

Surface FA

Bundle MD

Surface MD

Bundle FA

Surface FA

Unparcellated

-

0.03

-

-

-

-

-

-

Limbic

-

-

-

-

-

-

-

-

Executive

-

<0.001

-

-

-

-

-

-

Rostral Motor

-

0.01

-

-

-

-

-

-

Caudal Motor

-

-

-

-

-

-

-

-

Parietal

-

<0.001

-

-

-

-

-

-

Occipital

-

<0.001

-

-

-

-

-

-

 

post-hoc comparisons (ePD vs HC)

VTA, SNc

Bundle MD

Surface MD

Bundle FA

Surface FA

Bundle MD

Surface MD

Bundle FA

Surface FA

Unparcellated SNc

-

-

-

-

-

-

-

-

Limbic

-

-

-

-

-

-

-

-

Executive

-

-

-

<0.001

-

-

-

-

Rostral Motor

-

-

-

-

-

-

-

-

Caudal Motor

-

0.004

-

-

-

<0.001

-

-

Striatum

Bundle MD

Surface MD

Bundle FA

Surface FA

Bundle MD

Surface MD

Bundle FA

Surface FA

Unparcellated

-

-

-

-

-

-

-

-

Limbic

-

-

-

-

-

-

-

-

Executive

-

-

-

-

-

-

-

-

Rostral Motor

-

-

-

-

-

-

-

-

Caudal Motor

-

-

-

-

-

-

-

-

Parietal

-

-

-

-

-

-

-

-

Occipital

-

-

-

-

-

-

-

-

  1. Cells show adjusted p values of the main effect of Group and post-hoc comparisons for the dMRI features in the VTA, SNc and striatum regions of interest of the local Western and PPMI datasets following Bonferroni correction. Surface MD in the caudal motor SNc was significant in both datasets.
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