Table 1 Clinical and demographic characteristics of the study cohort

From: Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences

 

Overall

MSA overall

PD

p (MSA vs PD)

N (%)

87

(100.0)

49

(100.0)

38

(100.0)

 

 MSA-P

  

28

(57.1)

   

 MSA-C

  

21

(42.9)

   

Diagnostic certainty

 Possible, n (%)

  

10

(20.4)

   

 Probable, n (%)

  

39

(79.6)

   

Sex

      

0.11

 Women, n (%)

38

(43.7)

25

(51.0)

14

(36.8)

 

 Men, n (%)

49

(56.3)

24

(49.0)

24

(63.2)

 

Age

 Age at study entry, mean (SD)

65.0

(9.8)

63.7

(8.8)

66.5

(10.7)

0.19

 Age at primary diagnosis, mean (SD)

60.4

(10.7)

61.8

(8.9)

58.5

(12.4)

0.16

Time since primary diagnosis in years, mean (SD)

4.8

(4.9)

2.1

(1.7)

8.3

(5.5)

>0.001

Hoehn and Yahr stage, mean (SD)

3.2

(1.0)

3.6

(0.9)

2.7

(0.8)

>0.001

 Stage 1, n (%)

2

(2.3)

0

(0.0)

2

(5.3)

 

 Stage 2, n (%)

19

(21.8)

4

(8.2)

15

(39.5)

 

 Stage 3, n (%)

40

(46.0)

23

(46.9)

17

(44.7)

 

 Stage 4, n (%)

15

(17.2)

12

(24.5)

3

(7.8)

 

 Stage 5, n (%)

11

(12.6)

10

(20.4)

1

(2.6)

 

Scales

 UPDRS I mean (SD)

2.7

(2.0)

2.7

(2.6)

2.7

(2.1)

0.82

 UPDRS II mean (SD)

14.3

(7.5)

24.0

(8.9)

11.8

(4.6)

>0.001

 UPDRS III mean (SD)

30.4

(14.0)

43.6

(12.2)

23.3

(9.0)

>0.001

 UMSARS I mean (SD)

  

20.3

(6.8)

   

 UMSARS II mean (SD)

  

21.6

(7.6)

   

Treatment

 Levodopa treatment, n (%)

65

(74.7)

27

(55.1)

38

(100.0)

0.85

 Dopamine agonist treatment, n (%)

21

(24.1)

1

(2.0)

20

(52.6)

>0.001

 Levodopa response

      

>0.001

 Beneficial response, n (%)

51

(58.6)

13

(26.5)

38

(100.0)

 

 No or poor response, n (%)

28

(32.2)

28

(57.1)

0

(2.3)

 

 Unknown, n (%)

8

(9.2)

8

(16.3)

0

(0.0)

 

 Deep brain stimulation, n (%)

9

(10.3)

2

(4.1)

7

(18.4)

0.049

Secondary education

      

0.67

 ≤12 years, n (%)

37

(42.5)

23

(46.9)

14

(36.8)

 

 >12 years, n (%)

49

(56.3)

26

(53.1)

23

(60.5)

 

 Unknown, n (%)

1

(1.1)

0

(0.0)

1

(2.6)

 

Quality of life

 Motor subscore, mean (SD)

58.0

(23.5)

45.1

(20.9)

74.7

(14.4)

>0.001

 Nonmotor subscore, mean (SD)

63.4

(15.6)

58.5

(15.2)

69.6

(14.1)

>0.001

 Emotional subscore, mean (SD)

67.9

(20.4)

58.9

(18.9)

79.7

(15.7)

>0.001

Satisfaction with life situation, mean (SD)

47.1

(24.7)

37.6

(24.2)

60.1

(18.9)

>0.001

Risk propensity score, mean (SD)

17.8

(6.2)

17.3

(6.7)

18.4

(5.4)

0.41

Depression present, n (%)

30

(34.5)

17

(34.7)

13

(34.2)

0.92

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