Fig. 1: Nigrostriatal degeneration following viral-mediated expression of alpha-synuclein in the SNc. | npj Parkinson's Disease

Fig. 1: Nigrostriatal degeneration following viral-mediated expression of alpha-synuclein in the SNc.

From: Alpha-synuclein-induced nigrostriatal degeneration and pramipexole treatment disrupt frontostriatal plasticity

Fig. 1

A Representative images of the SNc in sham (top) and lesioned rats (bottom). B Stereological counts of tyrosine hydroxylase (TH)-positive neurons in the SNc. C Stereological counts of tyrosine TH- positive plus Nissl-stained neurons in the SNc. GFP SALINE (N = 17); GFP PPX (N = 20); alpha-SYN SALINE (N = 19); alpha-SYN PPX (N = 20). D Representative images of striatal TH immunofluorescence in sham and lesioned rats. Scale bar = 1 mm. E Quantification of fluorescence intensity in rats used for electrophysiology experiments. GFP SALINE (N = 12); GFP PPX (N = 14); alpha-SYN SALINE (N = 14); alpha-SYN PPX (N = 13). ***P < 0.001 and ****P < 0.0001; two-way ANOVA followed by Tukey’s post hoc.

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