Fig. 4: Nigrostriatal degeneragtion and PPX impair frontostriatal plasticity. | npj Parkinson's Disease

Fig. 4: Nigrostriatal degeneragtion and PPX impair frontostriatal plasticity.

From: Alpha-synuclein-induced nigrostriatal degeneration and pramipexole treatment disrupt frontostriatal plasticity

Fig. 4

A Schematic representation of OFC stimulation and DMS recording sites with examples of stimulation and recording tracks (arrowhead). B Representative electrophysiological traces of spike responses evoked in DMS neurons by OFC stimulation in the different groups. Black traces represent trials that do not exhibit spike responses to OFC stimulations and colored traces represent trials exhibiting spike response to OFC stimulation both before (baseline, blue) and after (post-HFS, green) high-frequency stimulation of the OFC-DMS pathway. Spike probability was measured as the number of responding trials over 5 min. C Spike probability (% of baseline) 15 before and 30–45 min after HFS. Delta change of response probability after HFS compared to baseline (%). GFP SALINE (N = 6); GFP PPX (N = 6); alpha-SYN SALINE (N = 6); alpha-SYN PPX (N = 6); ****P < 0.0001; two-way ANOVA followed by Tukey’s post hoc.

Back to article page