Fig. 1: αSyn overexpression and microbiome presence alter global metabolomic profiles in mice.
From: α-synuclein overexpression and the microbiome shape the gut and brain metabolome in mice
a tSNE plot of all metabolomic samples in this study, colored by tissue. b UpSet plot of unique and shared metabolite sets across all samples. Intersection size describes the number of metabolites with a significant genotype×microbiome interaction effect (p < 0.05). The dots below the bar chart indicate the sample source of the metabolites. Singular dots with no vertical lines connecting to other tissues indicate a set of metabolites which are uniquely altered in a particular tissue. c Stacked barplots depicting average effect sizes for biochemical classes containing molecules significantly associated (p < 0.05) with either a genotype, microbiome, or interaction effect in a linear regression model.
