Fig. 5: Morphological alterations in SNpr induced by LPS in Snca+/+ rats. | npj Parkinson's Disease

Fig. 5: Morphological alterations in SNpr induced by LPS in Snca+/+ rats.

From: Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson’s disease overexpressing human alpha synuclein

Fig. 5

a Representative image of coronal midbrain slice from DAB-stained SNpr TH+ fibers in WT and Snca+/+ rats treated with SAL or LPS (scale: 50 µm) and related micrographs (scale: 10 µm). Black arrowheads show swollen TH+ dendrites morphology. b SNpr TH+ fibers densitometric analysis. Values are expressed as means of each animal normalized to the total mean value of SAL WT group ± SEM. (n = 5 rats/group; Ordinary two-way ANOVA for Genotype vs Treatment: Interaction, F (1, 16) = 6.614, p = 0.0205; Genotype, F (1, 16) = 8.053, p = 0.0119; Treatment, F (1, 16) = 6.497, p = 0.0214; *p < 0.05, **p < 0.01, with Bonferroni’s post hoc multiple comparisons test).

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