Fig. 4: Increased TH+ fiber densities from 6-OHDA (20 µg; 2 weeks post-infusion). | npj Parkinson's Disease

Fig. 4: Increased TH+ fiber densities from 6-OHDA (20 µg; 2 weeks post-infusion).

From: Mapping of catecholaminergic denervation, neurodegeneration, and inflammation in 6-OHDA-treated Parkinson’s disease mice

Fig. 4

Clusters with increased TH-IF from 6-OHDA after FDR correction and validation by fiber density measurements are shown. Data are split into columns based on the comparison of post hoc voxel-wise t-tests. Left: increased TH-IF in the ipsilateral (ipsi) hemisphere of 6-OHDA-treated mice compared to their contralateral (contra) hemisphere. Middle: increased TH-IF in the ipsilateral hemisphere of 6-OHDA-treated mice compared to the ipsilateral hemisphere of vehicle-infused mice. Right: increased TH-IF in the contralateral hemisphere of 6-OHDA-treated mice compared to the contralateral hemisphere of vehicle-infused mice. A 3D brain models of valid clusters. B Sunburst plots summarize regional volumes of valid clusters across levels of the ABA hierarchy. C Quantification of TH+ fiber densities for each cluster. The largest region of each cluster is noted. Valid cluster locations, volumes, and regional compositions are summarized in Table S3. It also has raw fiber densities for all clusters. Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001. Abbreviations are defined in the ABA and Table S3. Other abbreviations include: r = rostral.

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