Fig. 2: Dendritic pruning of SNc dopamine neurons in MCI-Park mice.
From: Morphological and functional decline of the SNc in a model of progressive parkinsonism
A Representative single cell images (left of arrows) and skeletonized reconstructions (right of arrows) from control and MCI-Park animals. B Sholl analysis of reconstructed SNc dopamine neurons at p30-34 (n = C:13/3; M:9/3; NS effect of genotype, p = 0.2164, Two-Way ANOVA) and p40-44 (N = C:12/3, M:6/4, effect of genotype p = 0.0004, Two-way ANOVA) (C) Summary data comparing capacitance between control (gray) and MCI-Park (red) animals at 30–34 days (n = C:9/3, M:16/5; p = 0.0003), 35–39 days (n = C:16/4, M:12/4; p = 0.0002), and 40–44 days (n = C:16/6, M:11/3; p < 0.0001; all groups Sidak’s test following two-way ANOVA). D Summary data comparing somatic volume between control (gray) and MCI-Park (red) animals at 30–34 days (n = C:9/2, M:5/2; p = 0.0021), and 40–44 days (n = C:12/3, M:6/4; p = 0.0053; Uncorrected Fisher’s LSD following two-way ANOVA,). Data are presented as mean ± SD. n reported as (cells/animals) for control (C) or MCI-Park (M) groups.
