Fig. 3: Loss of D2-mediated IPSCs and preservation of GABAB-mediated IPSC’s in early stages of dopamine cell decline.
From: Morphological and functional decline of the SNc in a model of progressive parkinsonism
A Representative D2R-mediated IPSC’s induced by 5 electrical stimuli at 40 Hz across age groups for Control (black) and MCI-Park (magenta) cells. B Summary data showing the maximum amplitude of D2R-mediated IPSCs at the indicated age ranges in Control (C) and MCI-Park (MCI-P) animals (p30-34: p = 0.0001; p35-39: p < 0.0001; p40-44 p = 0.0153; n: C p30-34: 13/3, p35-39: 11/3, p40-44: 30/7; MCI-P p30-34: 8/3, p35-39: 25/6, p40-44: 15/5). C Representative GABAB-mediated IPSCs induced by 5 electrical stimuli at 40 Hz at the indicated age ranges for Control (black) and MCI-Park (cyan) animals. D Summary data showing the maximum amplitude of GABAB-mediated IPSCs at the indicated age ranges in Control (C) and MCI-Park (MCI-P) animals.(p30-34: p = 0.1206; p35-39: p = 0.2150; p40-44 p = 0.4896; n: C p30-34: 10/2, p35-39: 10/2,p40-44: 10/2; MCI-P p30-34: 10/4, p35-39: 10/2, p40-44:19/5) All comparisons made using Sidak’s test following two-way ANOVA and summary data presented as mean ± SD. n are reported as (cells/animals).
