Fig. 4: Progressive decrease in D2 and GABA-B receptor signaling in the SNc of MCI-Park mice.
From: Morphological and functional decline of the SNc in a model of progressive parkinsonism
A Representative traces from p40-44 control (black) and MCI-Park (red) cells showing D2-mediated GIRK currents in response to 200 nM quinpirole and summary data of the maximum current density in control (gray) and MCI-Park (red) cells at 30–34 days (n = C:6/2, M:6/4; ns, p = 0.5660), 35–39 days (n = C:8/3, M:10/4; ns, p = 0.1041), and 40–44 days (n = C:9/6, M:9/3; p = 0.0010). B Representative traces from p40-44 control and MCI-Park cells in response to 10 µM quinpirole and reversal by sulpiride (300 nM) and summary data of the maximum current density in control (gray) and MCI-Park (red) at 30–34 days (n = C:8/5, M:9/6; ns, p = 0.0616), 35–39 days (n = C:6/3, M:5/3; p = 0.0007), and 40–44 days (n = C:6/4, M:5/2; p = 0.0002). C Representative traces from p40-44 control (black) and MCI-Park (blue) cells showing GABAB-mediated GIRK currents in response to 4 µM Baclofen and summary data from p30-34 (n = C:5/3, M:8/5; p = 0.0260), p35-39 (n = C:7/3, M:8/4; p < 0.0001) and p40-44 (n = C:10/3, M:10/3; p = 0.0002) animals. D Representative GABAB mediated GIRK currents from p40-p44 control and MCI-Park cells in response to 100 µM baclofen reversed by CGP-55845 (1 µM) and summary data in control (gray) and MCI-Park (blue) cells at p30-34 days (n = C:7/4, M:6/5; p = 0.0111), p35-39 days (n = C:6/3, M:5/3; p = 0.0062), and p40-44 days (n = C:6/4, M:6/3; p < 0.0001) All groups compared using Sidak’s test following two-way ANOVA and presented as mean ± SD. n reported as (cells/animals) for control (C) or MCI-Park (M) groups.
