Table 4 Cox regression models in the PPMI cohort

From: Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson’s disease: analysis of two cohorts

 

HR (95% CI)

P value

χ2 (df, P value)

Change in χ2 (Pfor change)

Delong test

Model 1

  

34.198 (df = 3, P < 0.001)

NA

NA

PIGD score

1.673 (1.296–2.160)

<0.001

   

Mean caudate uptake

0.268 (0.121–0.595)

0.001

   

CSF Aβ42

0.998 (0.997–1.000)

0.019

   

Model 2 = Model 1+ volume of VDC at four-year follow-up

37.171 (df = 4, P < 0.001)

5.449 (Pfor change = 0.020)

Z = 2.211, P = 0.027

PIGD score

1.764 (1.349–2.306)

<0.001

   

Mean caudate uptake

0.219 (0.097–0.492)

<0.001

   

CSF Aβ42

0.998 (0.996–0.999)

0.006

   

VDC volume at four-year follow-up

0.999 (0.998–1.000)

0.024

   
  1. CI confidence interval, CSF cerebrospinal fluid, HR hazard ratio, PIGD postural instability gait difficulty.
  2. Bold values identify statistical significance (P < 0.05).
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