Fig. 2: In silico analysis reveals shared genes and pathways between monogenic PD datasets. | npj Parkinson's Disease

Fig. 2: In silico analysis reveals shared genes and pathways between monogenic PD datasets.

From: Deciphering shared molecular dysregulation across Parkinson’s disease variants using a multi-modal network-based data integration and analysis

Fig. 2: In silico analysis reveals shared genes and pathways between monogenic PD datasets.

a Visual representation of PD-KG subset demonstrating relationships between cell lines used for midbrain organoid generation in individual experiments (yellow nodes) and genes from the top 100 significantly differentially expressed lists (blue nodes). D30 and D35 indicate that transcriptomics analysis was done for midbrain organoids at day 30 or 35 of culture, respectively. The colour of the edges indicates different datasets (GBA-red, LRRK2-purple, MIRO1-green, and SNCA-orange). b Visual representation of PD-KG subset demonstrating shared genes between the four PD datasets involvement in pathways (pathway source: Reactome). Blue nodes—genes; pink nodes—pathways. c Pathway overrepresentation analysis of the merged list of the top 100 significantly differentially expressed genes from all four PD datasets.

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