Table 1 Meta-analysis results of per-domain rare variant burden in LRRK2

From: LRRK2 rare-variant per-domain genetic burden in Parkinson’s Disease: association confined to the kinase domain

Domain

Exonic variants, PFDR

Non-synonymous (missense only), PFDR

CADD ≥ 20, PFDR

LOF, PFDR

ARM

0.55

0.85

0.80

0.80

ANK

0.26

0.15

0.57

0.85

LRR

0.92

0.90

0.80

0.85

Roc-COR

0.15

0.15

0.26

0.80

Kinase

1.61 × 10-22

1.54 × 10-23

3.09 × 10-24

0.31

WD40

0.80

0.80

0.24

1

  1. P P value, FDR false discovery rate, CADD Combined Annotation Dependent Depletion score, LOF loss-of-function.
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