Fig. 1: Lipid alterations in the postmortem Parkinson’s disease (PD). | npj Parkinson's Disease

Fig. 1: Lipid alterations in the postmortem Parkinson’s disease (PD).

From: The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes

Fig. 1

Relative concentrations of the indicate lipid species of: A esterified cholesterol (CE) (B) ceramide (Cer), C phosphatidylcholine (PC) and D phosphatidylserine (PS) in homogenates of different brain regions: substantia nigra pars compacta (SNpc), ventral tegmental area (VTA), hypothalamus (Hypo), substantia innominata (SI) of PD postmortem donors (n = 16 for each brain region). Lipid species were normalized to concentrations in Control samples (n = 14) (indicated by dotted lines). Data are means ± SD of independent biological replicates (n) analyzed by a two-way ANOVA. (A) CE: Interaction (F(16,365) = 22.84; ****p < 0.0001), B Cer: Interaction (F(44,876) = 12.01; ****p < 0.0001), (C) PC: Interaction (F(92,1752) = 14.61; ****p < 0.0001), (D) PS: Interaction (F(92,1752) = 11.98; ****p < 0.0001). For post-hoc analyses (A–D), Dunnett’s multiple comparison test with a single pooled variance was used for each brain region vs Controls. *p < 0.05, ** p < 0.01, ***p < 0.001 ****p < 0.0001.

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