Table 1 Lipid alterations in postmortem PD brains

From: The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes

Donors

(Brain region)

Lipid Groups

Lipid species

PD (SNpc v VTA)

Sterols

CE 18:1

CE 20:3

CE 22:6

Phospholipids

PC 40:7

PC 42:5

PS 36:2

PD vs Controls (SNpc)

Sterols

CE 18:1

CE 20:3

CE 22:6

Sphingolipids

Cer 20:0

Cer 20:1

Cer 22:0

Phospholipids

PC 32:0

PC 40:7

PC 42:5

PC 42:6

PS 36:2

PS 38:5

PEp 36:3

PEp 36:4

  1. Lipid species identified by random forest (RF) classification can discriminate within PD brains differentially susceptible brain regions (substantia nigra pars compacta (SNpc) vs ventral tegmental area (VTA) (upper row) and between PD brains and control brains at the SNpc (lower row).
  2. SNpc substantia nigra pars compacta, VTA ventral tegmental area, CE cholesteryl esters, PC phosphatidylcholine, PS phosphatidylserine, Cer ceramide, PEp plasmalogen phosphatidylethanolamine.
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