Table 2 Demographics and clinical characteristics of Parkinson’s disease patients in two subtypes

From: Identifying brain degeneration patterns in early-stage Parkinson’s disease: a multimodal MRI study

 

Subtype1

Subtype2

  

Variable

(n = 72)

(n = 107)

p value

Adj.p

Demographics

Age, years

63.86 ± 7.44

51.99 ± 9.59

<0.001

/

Sex, male

32 (44.44%)

68 (63.55%)

<0.001

/

Education, years

6.00 (6.80)

9.00 (5.00)

<0.001

/

Disease duration, years

1.82 (1.59)

1.64 (2.28)

0.365

/

HY stage

2.12 ± 0.49

1.86 ± 0.50

0.535

/

Motor symptoms

UPDRS-II

9.08 ± 4.93

6.05 ± 4.10

0.009

0.047

UPDRS-III

25.39 ± 12.88

16.93 ± 9.61

0.012

0.047

Tremor scores

4.43 ± 3.90

3.58 ± 2.89

0.382

0.412

Rigidity scores

6.32 ± 5.61

4.30 ± 3.40

0.041

0.075

Bradykinesia scores

12.10 ± 7.81

7.80 ± 5.81

0.019

0.047

Cognitive assessment

MMSE scores

24.71 ± 4.17

27.43 ± 3.48

0.020

0.047

AVLT long delayed recall

3.33 ± 2.80

4.73 ± 2.78

0.265

0.309

SFT-Animal Naming

12.69 ± 4.10

15.68 ± 5.01

0.194

0.247

DST (total)

10.79 ± 2.29

11.97 ± 2.86

0.061

0.095

SDMT (correct)

25.55 ± 12.64

39.59 ± 13.76

0.003

0.023

Other Non-Motor symptoms

GDS

3.42 ± 3.19

2.22 ± 2.66

0.013

0.047

RBDQ-HK (total)

19.08 ± 15.47

13.88 ± 12.26

0.847

0.847

PDQ-39

21.58 ± 19.76

13.01 ± 14.52

0.078

0.110

SCOPA-AUT

9.93 ± 7.08

5.61 ± 4.98

0.043

0.075

  1. All comparisons of clinical characteristics above were adjusted for age, sex, and education. FDR correction was applied for multiple comparisons. Significant p values are shown in bold. Continuous variables are presented as mean ± standard deviation or median (interquartile range); categorical data are presented as number (percentage).
  2. Adj.p p-value after FDR corrected, HY Hoehn–Yahr, UPDRS unified Parkinson’s disease rating scale, MMSE mini-mental state examination, AVLT auditory verbal learning test, SFT semantic fluency test, DST digit span test, SDMT symbol digit modalities test, GDS geriatric depression scale, RBDQ-HK rapid eye movement sleep behavior disorder questionnaire (Chinese University of Hong Kong version), PDQ-39 Parkinson’s disease questionnaire-39 items, SCOPA-AUT scale for outcomes in PD for autonomic symptoms.
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