Fig. 6: Complement C4 exacerbates α-syn aggregation and propagation in vivo. | npj Parkinson's Disease

Fig. 6: Complement C4 exacerbates α-syn aggregation and propagation in vivo.

From: Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson’s disease

Fig. 6

A Representative fluorescent double labeling of p-S129 α-syn and TH in SN sections from mice injected with PBS, C4, α-syn PFF, or α-syn PFF + complement C4. Scale bar = 50 μm. B Representative Immunohistochemistry images of mouse brain sections labeled with p-S129 α-syn. Scale bar = 50 μm. C Quantification of the percentage of p-S129-positive neurons in the ipsilateral SN.

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