Fig. 5: Target profile summaries and knowledge base “illuminate”.
From: A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets
A–C These represent one of the 59 target profile summaries created for the prioritized targets. A, B The first two slides summarize target diligence across scorecard categories such as therapeutic mechanism of action (MOA), efficacy evidence in preclinical PD models, patient biology, and therapeutic potential. C The third slide provides a summary of each key diligence area, along with a list of gaps in the target profile and associated risks in therapeutic development for the target. D A screenshot of the target profile page in the knowledge base displays the data collected during this round of prioritization and selection.
