Fig. 8: Both hαSyn expression and αSyn PFF deposition increase hyperconnectivity in the SNc, but not the VTA.
From: Parkinson’s paradox: alpha-synuclein’s selective strike on SNc dopamine neurons over VTA
A Left panel: Network graphs of the SNc for non-injected and the hαSyn-injected hemispheres (AAV-TH-hαSyn, 1 µL). B Network graphs of the SNc for non-injected and the αSyn PFF-injected hemispheres (PFF, 2 µg/µL; 1µL per hemisphere; 0.5µL in the SNc and 0.5µL in the VTA). C Bar graphs of the frequencies of normalized node strengths in non-injected versus hαSyn- or αSyn PFF-injected SNc. D Bar graphs of the frequencies of normalized node degree in non-injected versus hαSyn- or αSyn PFF-injected VTA. E–H Pie graphs of the frequencies of the node strength above the mean of non-injected and hαSyn- or αSyn PFF-injected side in the SNc and VTA. Data was collected from 3 - 5 mice with a sample size ranging from n = 14–46 nodes (t-test, *p < 0.05, ***p < 0.001).
