Table 3 Plasma postprandial ghrelin concentrations

From: Fasting and postprandial Ghrelin levels in Parkinson’s disease: a systematic review and meta-analysis

Authors

Postprandial total ghrelin

Postprandial active ghrelin

Fiszer et al.34

NA

NA

Unger et al.33

Mean±SD (pg/ml)

0min; p = n.s.

Control = 973 ± 318 vs Drug-naive PD = 859 ± 246

Control vs Under therapy PD = 868 ± 259

15min; p = n.s.

Control = 927 ± 347 vs Drug-naive PD = 772 ± 288

Control vs Under therapy PD = 856 ± 268

30min; p = n.s.

Control = 896 ± 319 vs Drug-naive PD = 835 ± 313

Control vs Under therapy PD = 846 ± 325

60min; p = n.s.

Control = 826 ± 286 vs Drug-naive PD = 745 ± 185

Control vs Under therapy PD = 859 ± 415

120min; p = n.s.

Control = 891 ± 253 vs Drug-naive PD = 752 ± 239

Control vs Under therapy PD = 811 ± 388

180min; p = 0.033

Control = 953 ± 336 vs Drug-naive PD = 778 ± 263

Control vs Under therapy PD = 785 ± 337

300min; p = n.s.

Control = 1072 ± 551 vs Drug-naive PD = 829 ± 269

Control vs Under therapy PD = 833 ± 357

NA

Song et al.26

Mean±SEM (pg/ml)a

0min

Control = 549.35 ± 43.97 vs PD = 403.38 ± 29.90

30min

Control = 484.28 ± 31.66 vs PD = 377.00 ± 19.35

90min

Control = 486.04 ± 26.38 vs PD = 343.59 ± 17.58

180min

Control = 628.49 ± 42.21 vs PD = 401.62 ± 24.62

Mean±SEM (pg/ml)a

0min

Control = 118.79 ± 14.12 vs PD = 127.61 ± 22.95

30min

Control = 87.01 ± 10.59 vs PD = 89.66 ± 11.47

90min

Control = 111.72 ± 10.60 vs PD = 72.89 ± 10.59

180min

Control = 255.59 ± 24.71 vs PD = 115.25 ± 15.89

Tarianyk et al.38

Median (Q1-Q3) (pg/ml)a

120 min

Control = 1365.37 (1133.33–1507.36) vs Mixed PD = 1382.69 (1165.59–1446.33); p = n.s.

Control vs Akinetic-rigid PD = 987.01 (896.97–1393.08); p = 0.047

NA

Pietraszko et al.37

NA

Mean±SD (pg/ml)

0min; p = 0.0001

Control = 250.9 ± 76.8 vs PD = 148.2 ± 51.08

30min; p = n.s.

Control = 182.1 ± 53.4 vs PD = 133.74 ± 50.46

60min; p = 0.042

Control = 162.3 ± 42.7 vs PD = 112.80 ± 50.37

120min; p = 0.002

Control = 171.1 ± 44.3 vs PD = 98.42 ± 34.66

180min; p = 0.0001

Control = 220.4 ± 71.2 vs PD = 142.09 ± 53.83

Hornsby et al.35

Mean±SEM (pg/ml)a

180min; p = n.s.

Control = 500.4 ± 294.26 vs PD = 566.1 ± 433.3

Control vs PD Dementia = 401.8 ± 250.62

Mean±SEM (pg/ml)a

180min; p = 0.0169

Control = 72.86 ± 48.07 vs PD = 112.0 ± 81.88

Control vs PD Dementia = 41.32 ± 51.61

Siervo et al.36

EMM ± SE (pg/ml)

5min; p = n.s.

Control = 6.23 ± 0.43 vs PD = 5.98 ± 0.30

Control vs PD-CI = 6.67 ± 0.77

15min; p = n.s.

Control = 6.19 ± 0.48 vs PD = 5.92 ± 0.35

Control vs PD-CI = 5.86 ± 0.40

30min; p = n.s.

Control = 6.16 ± 0.37 vs PD = 5.87 ± 0.25

Control vs PD-CI = 5.96 ± 0.32

60min; p = n.s.

Control = 5.95 ± 0.36 vs PD = 5.81 ± 0.25

Control vs PD-CI = 5.88 ± 0.31

120min; p = n.s.

Control = 6.02 ± 0.38 vs PD = 5.70 ± 0.26

Control vs PD-CI = 5.92 ± 0.33

180min; p = n.s.

Control = 6.22 ± 0.40 vs PD = 5.81 ± 0.28

Control vs PD-CI = 6.12 ± 0.35

EMM ± SE (pg/ml)

5min; p = n.s.

Control = 4.19 ± 0.44 vs PD = 3.99 ± 0.29

Control vs PD-CI = 4.02 ± 0.36

15min; p = n.s.

Control = 4.19 ± 0.45 vs PD = 3.83 ± 0.29

Control vs PD-CI = 3.57 ± 0.35

30min; p = n.s.

Control = 3.55 ± 0.34 vs PD = 3.59 ± 0.27

Control vs PD-CI = 3.85 ± 0.43

60min; p = n.s.

Control = 3.64 ± 0.42 vs PD = 3.51 ± 0.28

Control vs PD-CI = 3.44 ± 0.36

120min; p = n.s.

Control = 3.87 ± 0.52 vs PD = 3.67 ± 0.34

Control vs PD-CI = 3.82 ± 0.43

180min; p = n.s.

Control = 4.21 ± 0.54 vs PD = 3.92 ± 0.35Control vs PD-CI = 4.46 ± 0.43

Majeed; Al-Lami; AlGawwam39

NA

NA

  1. PD Parkinson Disease, PD-CI PD with cognitive impairment, SD Standard deviation, SEM Standard error of the mean, 95% CI Confidence interval, Q1 First quartile is the 25th percentile of the data set, Q3 Third quartile is the 75th percentile of the data set, EMM Estimated marginal means, SE Standard error, NA Not assessed.
  2. aThe data was transformed by estimation into mean ± SD for the meta-analysis.