Fig. 6: Schematic representation of a cortico-striatal synapse affected by oligomeric α-synuclein and the pharmacological action of Tulrampator. | npj Parkinson's Disease

Fig. 6: Schematic representation of a cortico-striatal synapse affected by oligomeric α-synuclein and the pharmacological action of Tulrampator.

From: Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms

Fig. 6

Illustration of a cortico-striatal synapse in which oligomeric α-synuclein (OSyn) reduces VGluT1 levels, impairs synaptic transmission, and causes deficits in long-term potentiation (LTP) and depression (LTD), while treatment with the ampakine Tulrampator restores VGluT1 expression, normal synaptic transmission, and LTD.

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