Table 2 Among PD-variants, associations with RBD in PD compared to prior PD-GWAS associations

From: Genome-wide association study of REM sleep behavior disorder in Parkinson’s disease

  

PD with and without RBD

PD15,37

Variant

Nearest gene

OR (95% CI)

p value

OR (95% CI)

p value

4:90636630

SNCA

0.85 (0.81–0.89)

2.46E−10a

1.17 (1.14–1.2)

1.13E−36

12:40734202

LRRK2

0.41 (0.28–0.61)

1.04E−05a

11.35 (9.44–13.63)

3.61E−148

4:90626111

SNCA

0.89 (0.84–0.95)

0.0001365a

1.32 (1.29–1.35)

3.89E−154

16:30977799

SETD1A

0.92 (0.88–0.97)

0.001952

1.09 (1.07–1.12)

5.12E−20

19:2341047

SPPL2B

1.09 (1.03–1.15)

0.002506

0.93 (0.91–0.95)

4.18E−10

17:43798308

CRHR1

1.19 (1.05–1.36)

0.008267

0.79 (0.75–0.84)

6.71E−16

3:28705690

LINC00693

0.95 (0.9–0.99)

0.02552

1.07 (1.05–1.09)

8.09E−12

  1. PD Parkinson’s disease, RBD REM sleep behavior disorder, OR (95% CI) odds ratio with relative 95% confidence interval.
  2. aVariant statistically significant after Bonferroni correction (α/number of variants = 0.00054).
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