Fig. 5: Hypnodensities modeling scored by U-Sleep in a control participant, as well as in a patient with Parkinson’s Disease (PD) without rapid eye movement sleep behavior disorder (RBD) [PD(-RBD)], and a patient with PD and RBD [PD(+RBD], all being the closest to the median of their group.
From: Sleep stage mixing is associated with poor prognosis in early Parkinson’s disease
![Fig. 5: Hypnodensities modeling scored by U-Sleep in a control participant, as well as in a patient with Parkinson’s Disease (PD) without rapid eye movement sleep behavior disorder (RBD) [PD(-RBD)], and a patient with PD and RBD [PD(+RBD], all being the closest to the median of their group.](http://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41531-025-01105-w/MediaObjects/41531_2025_1105_Fig5_HTML.png?as=webp)
Representative examples of hypnodensities are shown with derived sleep stage uncertainty (with the red dotted line indicating the 80% threshold) and mixing for W-REM and N2–N3 for each subject. Note how mixed REM sleep is prominent in the PD + RBD subjects compared to the control subjects.
