Fig. 3: Brain-region-specific alterations in PUFA-containing GPLs between Ctrl and MPTP, and non-LID and LID groups. | npj Parkinson's Disease

Fig. 3: Brain-region-specific alterations in PUFA-containing GPLs between Ctrl and MPTP, and non-LID and LID groups.

From: Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease

Fig. 3

a Schematic of a coronal non-human primate brain tissue section at −4 mm from the ac depicting different brain regions, with those evaluated labelled in red. Representative images of the [M-H]− ion of PI (40:6) in (from left to right) b Ctrl, c MPTP, d non-LID, and e LID brain tissue sections at −4 mm from the ac. All ion images are scaled to the maximum intensity of the individual ion. The ion images are RMS-normalized in panels b–e. Lateral resolution: 150 μm; scale bar: 9 mm. Results of statistical analysis using Student’s t-test of PUFA-containing GPLs f PI(40:6), g PI(40:7), h PC (36:4), i PC(38:3), j PS (38:3) and k PC(36:3) in the GPi, and l PE(40:6), m PC(40:7), and n PC(42:7) in the GPe. Changes were statistically evaluated between Ctrl and MPTP, and non-LID and LID, independently. Asterisks indicate significance: *P < 0.05; **P < 0.01; ns: not significant.

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