Fig. 2: Natta projection of the d-enantiomeric lead compound SVD-1 and its first optimized derivative SVD-1a.
From: Direct disassembly of α-syn preformed fibrils into α-syn monomers by an all-D-peptide
Amino acid residues marked in red were exchanged or added for improved bioavailability, membrane penetrance and inhibitory effects.
