Table 3 Two-level sample and biomarkers collection recommended for clinical studies investigating the contribution of immunity to the development and progression of Parkinson’s disease (PD), considering both scientific value and feasibility

From: “Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson’s disease”

 

Level 1 – essential

Level 2 - optional

Sample Collection

Serum

PMNCs

Plasma

CSF

PBMCs

Saliva

 

Urine

 

Faeces

Biomarkers

Immunophenotypes (immune cell subsets and inflammatory markers)

Functional immune assays

 

Proteomics

 

Transcriptomics