Table 3 Correlation matrix of kinematic parameters with clinical characteristics in the PD + AS group (n = 10)

From: Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson’s disease

	Mean lag time		Mean PAR		Lag_med1		Lag_med2
	ρ	p-value	ρ	p-value	ρ	p-value	ρ	p-value
Age at biopsy	0.049	0.894	0.049	0.894	−0.275	0.442	−0.322	0.364
Age at motor symptom onset	0.024	0.947	0.067	0.853	−0.295	0.407	−0.367	0.297
Duration of onset to biopsy	0.006	0.986	0.031	0.931	0.146	0.688	0.183	0.614
MDS-UPDRS total score	0.030	0.934	0.030	0.934	−0.196	0.588	−0.182	0.614
MDS-UPDRS Part I score	0.264	0.461	−0.227	0.528	−0.074	0.839	−0.055	0.880
MDS-UPDRS Part II score	−0.024	0.947	0.103	0.776	−0.284	0.426	−0.322	0.364
MDS-UPDRS Part III score	−0.280	0.432	0.335	0.343	−0.319	0.369	−0.293	0.412
HY	−0.348	0.324	0.348	0.324	−0.175	0.628	−0.087	0.811
MoCA	0.526	0.118	−0.557	0.094	0.742	0.014	0.762	0.010
FAB	−0.049	0.907	0.049	0.907	0.242	0.563	0.395	0.332
GDS	0.377	0.283	−0.359	0.309	0.073	0.840	0.049	0.894
NMSS total score	0.626	0.053	−0.559	0.093	0.336	0.342	0.328	0.354
NMSS Domain 1: Cardiovascular	−0.208	0.565	0.208	0.565	−0.448	0.194	−0.398	0.255
NMSS Domain 2: Sleep/Fatigue	0.414	0.235	−0.414	0.235	0.298	0.403	0.247	0.492
NMSS Domain 3: Mood/Cognition	0.471	0.169	−0.495	0.145	0.302	0.397	0.373	0.288
NMSS Domain 4: Perceptual problems/Hallucinations	−0.199	0.582	0.199	0.582	−0.218	0.546	−0.294	0.409
NMSS Domain 5: Attention/Memory	−0.374	0.287	0.405	0.245	−0.647	0.043	−0.519	0.124
NMSS Domain 6: Gastrointestinal tract	−0.522	0.122	0.522	0.122	−0.525	0.119	−0.522	0.122
NMSS Domain 7: Urinary	0.317	0.372	−0.226	0.530	0.104	0.775	0.019	0.958
NMSS Domain 8: Sexual functions	0.528	0.117	−0.528	0.117	0.224	0.534	0.295	0.408
NMSS Domain 9: Miscellaneous	−0.154	0.670	0.222	0.537	−0.385	0.272	−0.383	0.275
B-SIT	0.343	0.332	−0.368	0.296	0.404	0.246	0.274	0.443
RBDSQ	0.125	0.730	−0.075	0.836	−0.120	0.741	−0.082	0.823
LEDD	0.498	0.143	−0.413	0.235	0.349	0.324	0.213	0.555

Significant correlation coefficients are marked in bold.
PD Parkinson’s disease, AS alpha-synuclein, PAR protein aggregation rate, SD standard deviation, Lag_med1 median of the lag time of each positive replicate, Lag_med2 median of the first two replicates reaching the threshold in each positive test, MDS-UPDRS Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, HY Hoehn and Yahr stage, MoCA Montreal Cognitive Assessment, FAB Frontal Assessment Battery, GDS Geriatric Depression Scale, NMSS Non-Motor Symptoms Scale, B-SIT Brief Smell Identification Test, RBDSQ Rapid Eye Movement Sleep Behavior Disorder Screening Questionnaire, LEDD levodopa equivalent daily dose.

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Table 3 Correlation matrix of kinematic parameters with clinical characteristics in the PD + AS group (n = 10)

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