Fig. 2: Results from the linear mixed model comparing Parkinson’s disease with a GBA1 variant (GBA-PD) to Parkinson’s disease without a GBA1 variant (non-GBA-PD. | npj Parkinson's Disease

Fig. 2: Results from the linear mixed model comparing Parkinson’s disease with a GBA1 variant (GBA-PD) to Parkinson’s disease without a GBA1 variant (non-GBA-PD.

From: Modelling cholinergic and dopaminergic function over time in Parkinson’s disease with and without GBA1 variants

Fig. 2

Left (A): Voxel-wise results from the linear mixed model comparing Parkinson’s disease with a GBA1 variant (GBA-PD) to Parkinson’s disease without a GBA1 variant (non-GBA-PD). A significant main group effect was observed, showing a cluster of reduced ¹⁸F-FEOBV binding in the right precentral and middle frontal gyri in the GBA-PD group. Right (B): Boxplot of the residuals from a linear mixed-effects model for mean ¹⁸F-FEOBV uptake in this cluster with time since diagnosis, age, sex, and a random intercept for subject-level as a predictor. C Group-level trajectories of mean ¹⁸F-FEOBV uptake in this cluster across time. The line plot shows mean values (± standard error) for each group at different time points.

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