Fig. 5: Workflow describing the secondary analysis of publicly available genomic and transcriptomic datasets to deduce pathways and genes associated with aberrant α-syn in PD that are also shared with MDD and thus may potentially contribute to PDD or exacerbation of PD. | npj Parkinson's Disease

Fig. 5: Workflow describing the secondary analysis of publicly available genomic and transcriptomic datasets to deduce pathways and genes associated with aberrant α-syn in PD that are also shared with MDD and thus may potentially contribute to PDD or exacerbation of PD.

From: α-synuclein in Parkinson’s disease: a central point of convergence with depression

Fig. 5: Workflow describing the secondary analysis of publicly available genomic and transcriptomic datasets to deduce pathways and genes associated with aberrant α-syn in PD that are also shared with MDD and thus may potentially contribute to PDD or exacerbation of PD.

A Procurement and analysis of genomic datasets available on GWAS catalogue led to identification of 10 shared genetic loci associated with PD and MDD. All included PD datasets reported polymorphisms in SNCA so that the convergent genetic loci could be studied for potential link to α-syn pathology. B Procurement and analysis of transcriptomic datasets available on GEO omnibus led to identification of 57 shared differentially expressed genes (DEGs) associated with PD and MDD. The chosen dataset for PD differentially expressed SNCA so that the convergent genes could be studied for potential link to α-syn pathology. Figure created in BioRender. Phansupkar, A. (2025) https://BioRender.com/4rbsnjl.

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