Table 1 Shared genetic loci between PD patients with confirmed SNCA polymorphisms and patients with MDD
From: α-synuclein in Parkinson’s disease: a central point of convergence with depression
Mapped Gene | TMEM229B | RBMS3 | KCNS3 | IGSF9B | HLA-DRB1 - HLA-DQA1 | GPX6 | FSTL5 | DYRK1A | ASS1P14 - SYT10 | ASH1L | |
|---|---|---|---|---|---|---|---|---|---|---|---|
PD | SNP ID | rs1555399 | rs7617877 | rs76116224 | rs329648 | rs112485576; rs2760980 | rs143167264 | rs3053523 | rs2248244; rs11701722 | rs138895122 | rs145330152 |
Risk Allele | rs1555399-T | rs7617877-A | rs76116224-A | rs3802920-T; rs329648-T | rs112485576-A; rs2760980-A | rs143167264-TACACACACAC | rs3053523-AACTT | rs2248244-A; rs11701722-T | rs138895122-T | rs145330152-C | |
Chro. Region | 14q24.1 | 3p24.1 | 2p24.2 | 11q25 | 6p21.32 | 6p22.1 | 4q32.2 | 21q22.13 | 12p11.21 | 1q22 | |
Chro. Location | 14:67517653 | 3:28664273 | 2:17966582 | 11:133917106; 11:133895472 | 6:32610995; 6:32597424 | 6:28504100 | 4:161987969 | 21:37480059; 12:37398228 | 12:33075690 | 1:155401328 | |
MDD | SNP ID | rs140168167 | rs6783423; rs1874256 | rs144159691 | rs11825659; rs612823 | rs535777 | rs13191038 | rs553959375 | rs9974713 | rs59704095 | rs150027551 |
Risk Allele | rs140168167-T | rs6783423-A; rs1874256-A | rs144159691-T | rs11825659-G; rs612823-T | rs535777-? | rs13191038-C | rs553959375-G | rs9974713-? | rs59704095-C | rs150027551-C | |
Chro. Region | 14q24.1 | 3p24.1 | 2p24.2 | 11q25 | 6p21.32 | 6p22.1 | 4q32.2 | 21q22.13 | 12p11.21 | 1q22 | |
Chro. Location | 14:67531718 | 3:29721458; 3:28952692 | 2:18228248 | 11:133925624; 11:133964209 | 6:32609856 | 6:28515140 | 4:161752227 | 21:37445397 | 12:33020106 | 1:155451485 | |
