Table 2 Sociodemographic and clinical characteristics of healthy controls and the two RBD clusters
|  | HC (N = 52) | iRBD Cluster A (N = 25) | iRBD Cluster B (N = 15) | p HC vs Cluster A | p HC vs Cluster B | p Cluster A vs Cluster B |
|---|---|---|---|---|---|---|
Demographics | ||||||
 Age [years] | 62.83 ± 7.94 (40.72; 81.41) | 62.38 ± 6.46 (51.88; 73.82) | 68.90 ± 6.56 (58.67; 80.69) | 1.00 | 0.02 | 0.02 |
 Sex [M/F] | 31/21 | 23/2 | 10/5 | 0.004 | 0.66 | 0.04 |
 Disease duration [years] | / | 5.84 ± 1.55 (5; 10) | 7.27 ± 4.28 (5; 20) | / | / | 0.27 |
Sleep | ||||||
 RBDSQ | 0 ± 0 (0; 0) | 9.24 ± 1.64 (6; 12) | 10.20 ± 1.47 (7; 12) | <0.001 | <0.001 | 0.03 |
 PSQI | 2.45 ± 1.88 (0; 7) | 5.56 ± 2.92 (1; 12) | 7.60 ± 3.18 (3; 13) | <0.001 | <0.001 | 0.14 |
 ESS | 3.58 ± 2.19 (0; 10) | 4.16 ± 2.30 (0; 10) | 7.47 ± 5.24 (1; 21) | 1.00 | <0.001 | <0.001 |
Neurological evaluation | ||||||
 MDS-UPDRS I | / | 3.72 ± 3.27 (0; 13) | 7.40 ± 2.47 (4; 13) | / | / | 0.002 |
 MDS-UPDRS II | / | 0.64 ± 1.5 (0; 7) | 0.80 ± 1.15 (0; 4) | / | / | 1.00 |
 MDS-UPDRS III [Bradykinesia] | / | 2.96 ± 1.84 (1; 10) | 3.27 ± 1.39 (1; 6) | / | / | 1.00 |
 MDS-UPDRS III [Resting tremor] | / | 0.28 ± 0.98 (0; 4) | 0 ± 0 (0; 0) | / | / | 1.00 |
 MDS-UPDRS III [Postural/Kinetic tremor] | / | 0.64 ± 0.76 (0; 2) | 0.67 ± 1.05 (0; 3) | / | / | 1.00 |
 MDS-UPDRS III [Rigidity] | / | 1.56 ± 1.29 (0; 4) | 1.47 ± 1.25 (0; 4) | / | / | 1.00 |
 MDS-UPDRS III [Gait/Balance] | / | 0.08 ± 0.28 (0; 1) | 0.47 ± 0.64 (0; 2) | / | / | 0.32 |
 MDS-UPDRS III [Facial expression] | / | 0.28 ± 0.46 (0; 1) | 0.13 ± 0.35 (0; 1) | / | / | 1.00 |
 MDS-UPDRS III | / | 5.88 ± 2.73 (1; 11) | 6.27 ± 2.52 (3; 11) | / | / | 1.00 |
Neuropsychological assessment | ||||||
 Digit span backward | 4.90 ± 1.16 (3; 8) | 4.72 ± 1.10 (3; 8) | 4.07 ± 0.80 (3; 6) | 1.00 | 0.23 | 0.39 |
 Rey’s list immediate recall | 51.03 ± 7.78 (36.40; 67) | 46.64 ± 7.20 (33; 61) | 41.27 ± 9.86 (25; 57) | 0.60 | <0.001 | 0.07 |
 Rey’s list delayed recall | 11.35 ± 2.29 (7; 15) | 9.40 ± 2.40 (4; 14) | 7.93 ± 3.03 (3; 13) | 0.07 | <0.001 | 0.17 |
 Raven’s progressive matrices | 33.08 ± 2.45 (25; 36) | 31.40 ± 3.37 (24; 36) | 26.40 ± 5.69 (16; 34) | 0.17 | <0.001 | <0.001 |
 Attentive matrices | 54.78 ± 5.04 (39;60) | 54.60 ± 4.86 (46; 60) | 49.13 ± 7.05 (29; 59) | 1.00 | 0.01 | 0.07 |
 Token test | 34.50 ± 1.33 (31; 36) | 34.52 ± 1.17 (32; 36) | 32.87 ± 2.07 (28; 36) | 1.00 | 0.01 | 0.02 |
 Benson’s figure copy | 15.70 ± 0.76 (13; 17) | 14.96 ± 1.02 (13; 16) | 14.00 ± 1.56 (11; 16) | 0.02 | <0.001 | 0.07 |
 Benson’s figure recall | 11.30 ± 3.00 (4; 17) | 10.80 ± 2.36 (7; 16) | 9.07 ± 3.37 (3; 14) | 1.00 | 0.048 | 0.36 |
Motor functional assessment | ||||||
 9HPT | 21.15 ± 3.25 (12.50; 26.85) | 22.55 ± 3.10 (16.50; 29.51) | 25.47 ± 2.45 (22.10; 30.96) | 0.26 | <0.001 | 0.09 |
 10MWT – CS [s] | 8.03 ± 1.08 (5.99; 10.77) | 8.23 ± 0.88 (6.86; 10.30) | 8.79 ± 1.60 (6.18; 12.24) | 1.00 | 0.17 | 0.72 |
 5TSTS [s] | 10.51 ± 2.33 (7; 18) | 11.28 ± 2.54 (6.68; 16.20) | 12.13 ± 1.95 (9.46; 14.88) | 0.38 | 0.14 | 1.00 |
 DT cost TUG [%] | 6.75 ± 12.41 (-9.81; 49.07) | 9.69 ± 8.54 (-1.35; 25.73) | 21.93 ± 15.59 (-2.38; 54.51) | 1.00 | 0.003 | 0.045 |
Non-motor symptoms | ||||||
 Olfactory Loss [Y/N] | / | 10/15 | 7/8 | / | / | 1.00 |
 Constipation [Y/N] | / | 2/23 | 9/6 | / | / | <0.001 |
 Urinary dysfunction [Y/N] | / | 2/23 | 10/5 | / | / | <0.001 |
 Orthostatic hypotension [Y/N] | / | 1/24 | 0/15 | / | / | 0.86 |
Mood | ||||||
 Depressive symptoms [Y/N] | 5/46 | 2/23 | 1/14 | 1.00 | 1.00 | 1.00 |
