Fig. 2: Analysis of T cell activation and effector functions. | npj Parkinson's Disease

Fig. 2: Analysis of T cell activation and effector functions.

From: Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease

Fig. 2: Analysis of T cell activation and effector functions.The alternative text for this image may have been generated using AI.

Boxplots showing frequency of: (a) T cells among lymphocytes; (b) CD45RO+Tbet- cells among CD4 T cells; (c) CD45RO-Tbet+ cells among CD8 T cells; (d) CD8 T cells expressing CD11b; and (e) HLA-DR+ cells among CD4 and CD8 T cells in PwPD (n = 28) and HCs (n = 25 (a−c, e; n = 26 d). f UMAP plot showing a random group-stratified subset of 100,000 stimulated CD4 T cells (50,000 PD and 50,000 HC), coloured by FlowSOM cluster identity. g, h Groupwise (n = 26 PD, n = 26 HC) boxplots showing: (g) TNFα + CD4 T cell cluster frequency among stimulated CD4 T cells; and (h) TNFα MFI of cells belonging to the CD4 T cell TNFα+ cluster. i Scatter plot showing Spearman correlation analysis between the frequencies of TNFα + CD4 T cells and of CD45RO+Tbet- CD4 T cells in each study group. Group comparisons were performed using the t-test or the Wilcoxon rank-sum test, as appropriate. *p < 0.05 was considered statistically significant.

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