Fig. 3: MAIT cells exhaustion- and activation-associated phenotypes, MR1 tetramer binding, and cytokine production. | npj Parkinson's Disease

Fig. 3: MAIT cells exhaustion- and activation-associated phenotypes, MR1 tetramer binding, and cytokine production.

From: Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease

Fig. 3: MAIT cells exhaustion- and activation-associated phenotypes, MR1 tetramer binding, and cytokine production.The alternative text for this image may have been generated using AI.

a−c Boxplots showing frequency of: (a) MAIT cells among T cells; (b) HLA-DR+ among MAIT cells; (c) TIM-3 + PD-1+ among MAIT cells. d Scatter plot showing correlation between the proportion of TIM-3 + PD-1 + MAIT cells and participant Gastrointestinal Symptom Rating Scale (GSRS) score. e Boxplots showing MAIT cell MR1-5-OP-RU tetramer MFI. f Boxplots showing MR1-5-OP-RU tetramer MFI on MAIT cell CD4/CD8 subsets. g Scatter plot showing Spearman-rank correlation between CD8 MAIT cell MR1-tetramer MFI and the frequency of CCR9 + MAIT cells. h UMAP displaying a random group-stratified subset of 100,000 stimulated MAIT cells, coloured according to FlowSOM cluster identity. i Boxplot showing the frequency of the IFNγ + MAIT cell cluster among stimulated MAIT cells. Boxplots and scatter plots are coloured according to study group, and comparisons between PD (n = 28 a−g; n = 26 h, i) and HC (n = 25 a−g; n = 26 h, i) groups performed by t-test or Wilcoxon rank-sum test, as appropriate. Statistical significance is indicated as *p < 0.05, **p < 0.01.

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