Fig. 4: Phenotypic and functional characterisation of Vδ1 and Vδ2 T cells. | npj Parkinson's Disease

Fig. 4: Phenotypic and functional characterisation of Vδ1 and Vδ2 T cells.

From: Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson’s disease

Fig. 4: Phenotypic and functional characterisation of Vδ1 and Vδ2 T cells.The alternative text for this image may have been generated using AI.

a−i Groupwise (n = 28 PD, n = 26 HC) boxplots showing frequency of: (a) Vδ1 T cells among T cells; (b) CD27hi and CD27lo subpopulations among Vδ1 T cells; (c) Vδ2 T cells among T cells; (d) γδ28 + , γδ28-, γδ16, γδ16+ subpopulations among Vδ2 T cells; (e) CD27+ CD45RA+ ‘naïve’ among Vδ2 T cells; (f) CD27+ CD45RA- ‘central memory’ (CM) among Vδ2 T cells; (g) CD27- CD45RA- ‘effector memory’ (EM) among Vδ2 T cells; (h) CD27- CD45RA+ ‘TEMRA’ among Vδ2 T cells. i Groupwise (n = 26 PD, n = 26 HC) boxplots showing the frequency of stimulated Vδ2 T cells expressing IFNγ, TNFα, or both IFNγ and TNFα. Statistical comparisons performed by t-test or Wilcoxon rank-sum test, as appropriate. *p < 0.05 was considered statistically significant.

Back to article page