Fig. 4: Network integration of the neurodegeneration-related interactome from NDAtlas.
From: JNK3 quantification in plasma: a novel biomarker for neuronal damage in Parkinson’s disease
A Interaction network centered on MAPK8IP1 (JIP1), illustrating its connectivity with JNK kinases (MAPK9 and MAPK8), and α-Syn (SNCA). B Overlapping interaction networks of PD and AD highlighting the central connectivity role of MAPK8IP1 (JIP1). Interaction metrics: MAPK8IP1-SNCA Score: 0.6655, Confidence: 0.3010. Each node indicates a protein or gene associated with a neurodegenerative disease, color-coded as follows: gray for N/A, black for AD, blue for multiple pathologies, and purple for PD. Edges (lines) between nodes represent known or predicted interactions, such as physical binding or functional links.
