Table 1 Demographic and clinical characteristics of iRBD and different PD stages
From: JNK3 quantification in plasma: a novel biomarker for neuronal damage in Parkinson’s disease
HC (n = 28) | iRBD (n = 25) | De Novo (n = 26) | Late PD (n = 29) | HC vs iRBD | HC vs De Novo | HC vs Late PD | iRBD vs De Novo | iRBD vs Late PD | De Novo vs Late PD | |
|---|---|---|---|---|---|---|---|---|---|---|
Age (y) | 64.8 ± 9.9 | 65.7 ± 7.7 | 64.2 ± 11.4 | 66.0 ± 11.5 | 0.965 | 0.946 | 0.949 | 0.880 | 0.896 | 0.859 |
Biological Sex (%M) | 50.0 | 80.0 | 69.0 | 69.0 | 0.029 | 0.147 | 0.182 | 0.288 | 0.272 | 0.607 |
BMI | 23.9 [22.3-26.4] | 26.3 [23.4-28.0] | 24.9 [22.7-29.7] | 24.7 [21.6-27.3] | 0.065 | 0.278 | 0.810 | 0.694 | 0.128 | 0.415 |
Age of onset (y) | – | 63.5 ± 8.1 | 62.7 ± 11.5 | 59.5 ± 13.1 | – | – | – | 0.778 | 0.270 | 0.314 |
Disease duration (y) | – | 2.6 ± 1.6 | 1.8 ± 1.0 | 6.4 ± 3.1 | – | – | – | 0.570 | 0.000 | 0.000 |
H&Y | – | 1.0 [1.0-1.0] | 1.0 [1.0-2.0] | 2.0 [2.0-3.0] | – | – | – | 0.009 | 0.000 | 0.003 |
UPDRS-I | – | 6.5 [2.5-17.8] | 11.0 [3.0-14.5] | 5.5 [4.0-7.8] | – | – | – | 0.550 | 0.790 | 0.245 |
UPDRS-II | – | 1.0 [0.0-6.0] | 5.0 [3.0-10.5] | 6.5 [3.3-8.0] | – | – | – | 0.042 | 0.019 | 0.937 |
UPDRS-III | – | 6.0 [4.0-8.0] | 15.0 [10.0-24.0] | 11.5 [7.8-17.5] | – | – | – | 0.000 | 0.004 | 0.157 |
UPDRS-TOT | – | 13.5 [5.8-37.3] | 29.0 [21.5-50.0] | 24.5 [17.5-36.5] | – | – | – | 0.075 | 0.196 | 0.256 |
COMPASS-31_OH | – | 0.0 [0.0-12.0] | 0.0 [0.0-16.0] | 0.0 [0.0-6.0] | – | – | – | 0.566 | 0.440 | 0.167 |
COMPASS-31_VM | – | 0.0 [0.0-0.0] | 0.0 [0.0-0.0] | 0.0 [0.0-0.0] | – | – | – | 0.211 | 0.398 | 0.616 |
COMPASS-31_SM | – | 1.5 [0.0-4.2] | 2.1 [0.0-4.2] | 0.5 [0.0-4.2] | – | – | – | 0.947 | 0.607 | 0.555 |
COMPASS-31_GI | – | 4.5 [0.0-6.3] | 4.9 [1.6-7.7] | 1.8 [0.0-5.3] | – | – | – | 0.518 | 0.129 | 0.020 |
COMPASS-31_BL | – | 0.0 [0.0-2.1] | 0.0 [0.0-1.1] | 0.0 [0.0-1.1] | – | – | – | 0.333 | 0.156 | 0.617 |
COMPASS-31_PM | – | 0.8 [0.0-1.3] | 0.0 [0.0-1.5] | 0.0 [0.0-0.0] | – | – | – | 0.799 | 0.014 | 0.030 |
COMPASS-31_TOT | – | 14.2 [6.6-22.7] | 8.8 [4.8-27.3] | 7.1 [0.5-13.5] | – | – | – | 0.788 | 0.047 | 0.098 |
Beck_Depr | – | 8.0 [2.8-11.0] | 8.0 [3.5-17.0] | 5.0 [3.0-¨9.5] | – | – | – | 0.578 | 0.412 | 0.095 |
MMSE | – | 29.0 [28.0-30.0] | 30.0 [28.5-30.0] | 30.0 [29.0-30.0] | – | – | – | 0.229 | 0.037 | 0.464 |
MoCA | – | 26.0 [21.0-28.0] | 26.0 [22.0-28.5] | 29.0 [25.0-29.0] | – | – | – | 0.888 | 0.012 | 0.028 |
Smell test | – | 8.0 [6.0-10.0] | 6.0 [3.5-8.0] | 7.0 [4.0-9.5] | – | – | – | 0.042 | 0.305 | 0.346 |
RBDSQ | – | 10.0 [8.8-10.5] | 3.0 [2.0-6.5] | 4.0 [1.5-5.5] | – | – | – | 0.000 | 0.000 | 0.820 |
LEDD | – | 0.0 [0.0-0.0] | 70.0 [0.0-187.1] | 552.0 [302.5-725.0] | – | – | – | 0.000 | 0.000 | 0.000 |
